The genitourinary syndrome of menopause, with special reference to vulvovaginal atrophy, impacts on postmenopausal women’s quality of life. There is a rationale for exploring the effectiveness of vulvovaginal bio-revitalization with techniques similar to those successful in cutaneous bio-revitalization
(infiltration and topical application of polynucleotides and hyaluronic acid).
Methods: Prospective cohort study of women with post-menopausal vulvovaginal symptoms for at least 1 year; the interim results for the first 19 enrolled women are presented. Infiltrative bio-revitalization procedure: 3 priming sessions with highly concentrated polynucleotides from salmon trout gonads (40 mg/2 mL; bi- or three-weekly infiltrations) followed by 2 consolidation sessions with sodium hyaluronate (40 mg/2 mL) bi-weekly. Anesthetic cream applied before all infiltrations.
Evaluations: basally and after 21, 35, 50, 70 and 90 days.
Results: All women experienced rapid symptom improvement after the two first priming infiltrations (symptom scores falling between 42.2% and 52.6% vs. baseline),
with special reference to itching and soreness, tenderness and tingling (symptom scores, -52.6% and -51.6%, respectively). Dyspareunia and vaginal dryness scores
fell by 59.4% and 59.1%, respectively, at the end of follow-up.
Conclusion: The outcomes of this explorative study might suggest that both the documented bio-reactivating properties of polynucleotides in the skin and the
similarly documented synergy between polynucleotides and hyaluronic acid might also be expressed in post-menopausal vulvovaginal tissues, though confirmation by well-designed controlled trials is warranted.
Reference links：
https://www.oatext.com/pdf/OGR-3-135.pdf